Track 14: Gut–Liver, Gut–Kidney, and Gut–Lung Axis– 16th World Probiotics, Nutrition, Gut Health Conference and Exhibition

 Attend the 16th World Probiotics, Nutrition & Gut Health Conference and Exhibition

December 17–19, 2026 | Dubai, UAE

Introduction:       

In recent years, microbiome research has transformed our understanding of human health. The gut is no longer viewed as a standalone digestive organ — it is now recognized as a central regulator of systemic physiology. Through complex biochemical, immune, and metabolic signaling pathways, the gut microbiota communicates continuously with distant organs, shaping their function and influencing disease progression.

The concept of the Gut–Liver, Gut–Kidney, and Gut–Lung Axis highlights this interconnected network. These axes describe the bidirectional relationship between intestinal microbiota and major organs responsible for metabolism, detoxification, filtration, and respiratory defense. When the gut microbiome is balanced, it supports immune homeostasis, metabolic regulation, and organ protection. However, when dysbiosis occurs, inflammatory mediators and microbial toxins can circulate throughout the body, contributing to chronic liver disease, kidney dysfunction, and respiratory disorders.

Track 14: Gut–Liver, Gut–Kidney, and Gut–Lung Axis: at the 16th World Probiotics, Nutrition, Gut Health Conference and Exhibition, this emerging field represents a critical frontier in translational medicine. By exploring how microbial metabolites, immune signaling, and barrier integrity influence multi-organ health, researchers and clinicians are uncovering innovative therapeutic strategies aimed at restoring systemic balance through targeted microbiome modulation.

 What is the Gut–Liver, Gut–Kidney, and Gut–Lung Axis?

The Gut–Liver, Gut–Kidney, and Gut–Lung Axis refers to the bidirectional communication pathways between the gut microbiota and distant organs such as the liver, kidneys, and lungs.

The gut is not an isolated digestive organ — it acts as a central hub of immune regulation, metabolism, and systemic signaling. Through microbial metabolites, immune mediators, neural pathways, and circulating toxins, the gut microbiome influences the function and health of these major organs.

This concept is part of a broader systems-biology approach that recognizes the body as an interconnected network rather than isolated organ systems.

Description of Each Axis

1️ Gut–Liver Axis

The gut and liver are directly connected through the portal vein, which carries nutrients, microbial metabolites, and bacterial components from the intestine to the liver.

When gut microbiota becomes imbalanced (dysbiosis), harmful substances such as endotoxins can enter circulation and contribute to liver inflammation and metabolic disorders. This axis plays a major role in:

• Fatty liver disease
• Liver fibrosis
• Cirrhosis
• Hepatic inflammation

2️ Gut–Kidney Axis

The gut microbiome influences kidney function through the production of uremic toxins, inflammatory mediators, and metabolic byproducts.

In chronic kidney disease (CKD), gut dysbiosis worsens toxin accumulation, creating a harmful cycle between the gut and kidneys. This axis affects:

• Chronic kidney disease progression
• Renal inflammation
• Cardiovascular complications related to kidney dysfunction

3️Gut–Lung Axis

The gut and lungs communicate through immune signaling pathways and microbial metabolites such as short-chain fatty acids (SCFAs).

Gut microbiota plays a role in regulating respiratory immunity and inflammatory responses. Imbalances in gut microbes may influence:

• Asthma
• COPD
• Respiratory infections
• Allergic airway diseases

Types of Communication Mechanisms

These axes function through multiple pathways:

1. Microbial Metabolites

Short-chain fatty acids, bile acids, trimethylamine-N-oxide (TMAO), and uremic toxins.

2. Immune Signaling

Cytokines and immune cell modulation triggered by gut bacteria.

 3. Circulatory Pathways

Transport of bacterial components and metabolites via bloodstream.

 4. Neuroendocrine Signaling

Gut-derived signals influencing systemic inflammation and organ function.

Effects on Human Health

The impact of these gut-organ axes includes:

• Increased systemic inflammation
• Metabolic imbalance
• Immune dysregulation
• Organ fibrosis and degeneration
• Higher risk of chronic diseases

On the positive side, a balanced microbiome can:

• Improve liver metabolism
• Reduce kidney toxin load
• Enhance lung immune defense
• Lower chronic inflammation

Professionals Involved

This field brings together multiple specialties, including:

• Gastroenterologists
• Hepatologists
• Nephrologists
• Pulmonologists
• Clinical nutritionists
• Microbiome researchers
• Immunologists
• Pharmaceutical and probiotic developers

The interdisciplinary collaboration showcased at the 16th World Probiotics Conference is essential for advancing clinical applications.

Solving the Challenges: Therapeutic Approaches

Emerging strategies to target these axes include:

✅ Probiotics and Synbiotics

To restore microbial balance and reduce systemic inflammation.

✅ Precision Nutrition

Personalized dietary interventions to modulate gut microbiota.

✅ Prebiotics and Postbiotics

To support beneficial microbial metabolites.

✅ Microbiome-Based Therapeutics

Targeted bacterial strains designed for organ-specific benefits.

✅ Lifestyle and Metabolic Management

Diet, exercise, and stress regulation to improve gut integrity.

Conclusion

The Gut–Liver, Gut–Kidney, and Gut–Lung Axis represents a transformative shift in modern medicine. Instead of treating organs independently, science now recognizes the gut microbiome as a central regulator of systemic health.

Understanding and modulating these interconnected pathways opens new possibilities for preventing and managing chronic liver disease, kidney disorders, and respiratory conditions.

Track 14: Gut–Liver, Gut–Kidney, and Gut–Lung Axis: at the 16th World Probiotics, Nutrition, Gut Health Conference and Exhibition, this topic stands at the forefront of innovation  connecting microbiome science with real-world clinical solutions.

Information:

Conference name: 16th World Probiotics, Nutrition, Gut Health Conference and Exhibition, December 17–19, 2026, in Dubai, UAE
date:
location: Dubai,UAE
registration: https://probiotics-guthealth.utilitarianconferences.com/registration
submit abstract: https://probiotics-guthealth.utilitarianconferences.com/submit-abstract
online registration link